It's not the big things. The big things you can dig your heels in and deal with.
It's the tiny, pesky things that, cumulatively, really start to frost you. (Well, by "you," I of course mean "me.")
Dental floss that breaks in the middle of flossing.
The garbage truck coming an hour earlier than it ever has before, so you miss it and have keep stinky garbage around until the next pick-up day, when the truck comes so late your embarrassingly overflowing can has to stay by the curb all...day...long.
The grocery store being out of the one thing you really need.
When you forget you're wearing your contact lenses and accidentally rub your eye, pushing the lens up God knows where under your eyelid.
When the brilliant idea for your WIP evaporates somewhere between your brain and your fingers as you type. (Heh. If only it were this easy...)
Out. Of. CHOCOLATE!! (Okay, that's really a major irritant.)
Those squirrelly two-second power outages--just long enough that you have to reset all the digital clocks in the house.
When the guy with the Harley across the street idles it for-freakin'-ever, early in the morning, on a day you (again, by "you," I mean "me") could be sleeping in.
Trigger-powered spray bottles that inexplicably stop working when there is still liquid in them.
Shoestrings that break at inopportune moments.
Care to add to the list? What are your minor irritants? Go ahead. Get it off your chest. You'll feel better.